《科学》:深度打击潜伏的HIV!科学家发现可识别HIV蛋白酶,启动感染细胞程序性死亡的炎性小体,有助于彻底消灭体内病毒库(6)

2023-04-24 来源:飞速影视
[7] Johnson DC, Okondo MC, Orth EL, et al. DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes. Cell Death Dis. 2020;11(8):628. Published 2020 Aug 14. doi:10.1038/s41419-020-02865-4
[8] Figueiredo A, Moore KL, Mak J, Sluis-Cremer N, de Bethune MP, Tachedjian G. Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol. PLoS Pathog. 2006;2(11):e119. doi:10.1371/journal.ppat.0020119
[9] Jochmans D, Anders M, Keuleers I, et al. Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease. Retrovirology. 2010;7:89. Published 2010 Oct 15. doi:10.1186/1742-4690-7-89
[10] Zerbato JM, Tachedjian G, Sluis-Cremer N. Nonnucleoside Reverse Transcriptase Inhibitors Reduce HIV-1 Production from Latently Infected Resting CD4 T Cells following Latency Reversal. Antimicrob Agents Chemother. 2017;61(3):e01736-16. Published 2017 Feb 23. doi:10.1128/AAC.01736-16
[11] Trinité B, Zhang H, Levy DN. NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal. Retrovirology. 2019;16(1):17. Published 2019 Jun 26. doi:10.1186/s12977-019-0479-9
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