I类HDACs是乳酸化修饰“eraser”(4)

图4 HDAC3对多种PTMs的催化效率比较总而言之，此项研究中利用荧光标记肽段、重组蛋白HDACs、Hela细胞系等多种实验材料，首次系统性地探索了乳酸化修饰“eraser”，揭示了I类HDACs (HDAC1-3)和SIRT1-3 的去乳酸化修饰活性，并且深入探讨了HDAC1-3对细胞组蛋白乳酸化修饰的调控作用，这些结果为未来实现乳酸化修饰的精细调控奠定了坚实的理论基础。最后，我们也祝愿此项乳酸化修饰里程碑式研究能够在不久的将来顺利正式发表。
参考文献：
1. Gianluca Figlia, Philipp Willnow, and Aurelio A. Teleman,et al., 2020. Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins.Development Cell.
2. Di Zhang,et al., 2019. Metabolic regulation of gene expression by histone lactylation.Nature.
3. Erika L. Varner,et al., 2020. Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues.Open Biol.
4. Dominique O. Gaffney,et al., 2020. Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes.Cell Chem Biol.
5. Carlos Moreno-Yruela,et al., 2021. Class I Histone Deacetylases (HDAC1–3) are Histone Lysine Delactylases.bioRxiv.
本文由景杰学术团队报道，欢迎转发到朋友圈。如有转载、投稿等其他合作需求，请文章下方留言，或添加微信ptm-market咨询。